GATA3 (clone 7B5), anti-human

Protein Family: Transcription Factors

Pathway and Disease: Transcription

Description:
GATA3 (GATA binding protein 3) is an enhancer-binding protein containing a zinc finger domain. The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. A common TCR regulatory element was identified by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells, macrophages, or HeLa cell lines. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers.

Alternate Names: HDR, Trans-acting T-cell-specific transcription factor GATA-3 , GATA-binding factor 3

Application Notes: E: 1:10000; WB: 1:500-1:2000; IHC: 1:200-1:1000

Accession No.: P23771

Antigen: Purified recombinant fragment of human GATA3 expressed in E. coli

Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.