GATA4 (clone 6H10), anti-human, mouse
€443.00
In stock
SKU
252901
Catalog Nr.: 252901
Size: 0.1 ml
Isotype: Mouse IgG2b
Applications: WB
Size: 0.1 ml
Isotype: Mouse IgG2b
Applications: WB
Protein Family: Transcription Factors
Pathway and Disease: Transcription
Description:
GATA4 (GATA binding protein 4) is a 46 kDa member of the GATA family of zinc-finger transcription factors. Members of this family is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. These factors recognize the GATA motif which is present in the promoters of many genes. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1/2, and weakly through JNK or p38 MAPKs. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations have been associated with cardiac septal defects.
Alternate Names: Transcription factor GATA-4, GATA-binding factor 4, GATA4
Application Notes:
Accession No.: P43694
Antigen: Purified recombinant fragment of human GATA4 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Transcription
Description:
GATA4 (GATA binding protein 4) is a 46 kDa member of the GATA family of zinc-finger transcription factors. Members of this family is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. These factors recognize the GATA motif which is present in the promoters of many genes. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1/2, and weakly through JNK or p38 MAPKs. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations have been associated with cardiac septal defects.
Alternate Names: Transcription factor GATA-4, GATA-binding factor 4, GATA4
Application Notes:
Accession No.: P43694
Antigen: Purified recombinant fragment of human GATA4 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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