GDF6 polyclonal, anti-human, mouse, rat

GDF6 polyclonal, anti-human, mouse, rat

€347.00
In stock
SKU
253907
Catalog Nr.: 253907
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB
Protein Family: Enzymes

Pathway and Disease: Signaling Molecules and Interaction

Description:
Growth differentiation factors (GDFs) are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. Both GDF6 and GDF7 are closely related to GDF5 which has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. In Xenopus, GDF6 is expressed at the edge of the neural plate and within the anterior neural plate including the eye fields. GDF6 is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. It may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins (BMPs), and control eye development. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation.

Alternate Names: GDF6 , Growth Differentiation Factor 6, GDF16, GDF-6, CDMP2

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500

Accession No.: NP_001001557

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human GDF6.

Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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