GDNF mouse active recombinant protein
€295.00
In stock
SKU
600362
Protein Family: Cytokines
Pathway and Disease: Cell Growth and Death, Development and Behavior, Nervous and Sensory Systems, Signaling Molecules and Interaction
Alternate Names: Glial cell line-derived neurotrophic factor, astrocyte-derived trophic factor, ATF, GDNFDescription:
Glial Cell Line-Derived Neurotrophic Factor, or GDNF, is a neurotrophic factor that is closely related to other neurotrophic factors such as Neurturin, Persephin, and Artemin, by a common structural feature called the cysteine-knot. GDNF signals through a multicomponent system of receptors that includes receptors known as RET, and GFRalpha 1-4 to promote dopamine uptake, survival and differentiation of neurons. Mouse GDNF is produced in E.coli. Recombinant mouse GDNF is a non-glycosylated homodimer, containing two 135 amino acid chains, with a total molecular weight of 30.2 kDa.
Source: E. coli. Endotoxin level as measured by LAL is <0.05ng/ug or <0.5EU/ug.
Applications: E, WB
Application Notes:
The activity is determined by the dose-dependent proliferation of C6 cells and is typically less than 1 ug/mL. Specific activity: 1 x 10e3 units/mg
Accession No.: P48540
MW: 30200 Da
Sequence:
MSPDKQAAL PRRENRNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI
Purity:
Purity > 95% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
Format:
Each vial contains 10 ug of lyophilized protein. Reconstitute with 0.1 ml sterile deionized water for a final concentration of 0.1 mg/ml.
Storage: Store at -20°C. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. We recommend to add a carrier protein (0.1% HSA or BSA) for long term storage.
Pathway and Disease: Cell Growth and Death, Development and Behavior, Nervous and Sensory Systems, Signaling Molecules and Interaction
Alternate Names: Glial cell line-derived neurotrophic factor, astrocyte-derived trophic factor, ATF, GDNFDescription:
Glial Cell Line-Derived Neurotrophic Factor, or GDNF, is a neurotrophic factor that is closely related to other neurotrophic factors such as Neurturin, Persephin, and Artemin, by a common structural feature called the cysteine-knot. GDNF signals through a multicomponent system of receptors that includes receptors known as RET, and GFRalpha 1-4 to promote dopamine uptake, survival and differentiation of neurons. Mouse GDNF is produced in E.coli. Recombinant mouse GDNF is a non-glycosylated homodimer, containing two 135 amino acid chains, with a total molecular weight of 30.2 kDa.
Source: E. coli. Endotoxin level as measured by LAL is <0.05ng/ug or <0.5EU/ug.
Applications: E, WB
Application Notes:
The activity is determined by the dose-dependent proliferation of C6 cells and is typically less than 1 ug/mL. Specific activity: 1 x 10e3 units/mg
Accession No.: P48540
MW: 30200 Da
Sequence:
MSPDKQAAL PRRENRNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI
Purity:
Purity > 95% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
Format:
Each vial contains 10 ug of lyophilized protein. Reconstitute with 0.1 ml sterile deionized water for a final concentration of 0.1 mg/ml.
Storage: Store at -20°C. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. We recommend to add a carrier protein (0.1% HSA or BSA) for long term storage.
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