Gelsolin (clone ), anti-human
€966.00
In stock
SKU
250229
Catalog Nr.: 250229
Size: 0.2 mg
Isotype: Mouse IgG1/k
Applications: E, WB
Size: 0.2 mg
Isotype: Mouse IgG1/k
Applications: E, WB
Protein Family: Enzymes
Pathway and Disease: Folding, Sorting and Degradation, Cell Motility
Description:
Gelsolin participates in the extracellular actin scavenger system, binding actin and disaggregating filamentous actin released from dying cells. Actin monomers are then transferred to Gc-globulin. The plasma concentration of gelsolin is reduced in conditions of major actin release, such as acute liver failure, major trauma and rhabdomyolysis, where multi-organ failure is a risk. It has been suggested that gelsolin, like Gc-globulin, can be a prognostic factor in these conditions. This antibody binds human gelsolin.
Alternate Names: Actin-depolymerizing factor, ADF, Brevin, AGEL
Application Notes: The ELISA dilution guideline applies to gelsolin immobilized on microplate coated with a polyclonal capture antibody. Product Cat. No. 250229 does not work as capture antibody in sandwich ELISA. E: 1:4,000; WB:1:100-1:500
Accession No.: P06396
Antigen: Gelsolin purified from human plasma
Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Folding, Sorting and Degradation, Cell Motility
Description:
Gelsolin participates in the extracellular actin scavenger system, binding actin and disaggregating filamentous actin released from dying cells. Actin monomers are then transferred to Gc-globulin. The plasma concentration of gelsolin is reduced in conditions of major actin release, such as acute liver failure, major trauma and rhabdomyolysis, where multi-organ failure is a risk. It has been suggested that gelsolin, like Gc-globulin, can be a prognostic factor in these conditions. This antibody binds human gelsolin.
Alternate Names: Actin-depolymerizing factor, ADF, Brevin, AGEL
Application Notes: The ELISA dilution guideline applies to gelsolin immobilized on microplate coated with a polyclonal capture antibody. Product Cat. No. 250229 does not work as capture antibody in sandwich ELISA. E: 1:4,000; WB:1:100-1:500
Accession No.: P06396
Antigen: Gelsolin purified from human plasma
Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
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