Gelsolin (clone GEL-42), anti-human, mouse, rat
€362.00
In stock
SKU
251751
Catalog Nr.: 251751
Size: 0.1 mg
Isotype: Mouse IgG1
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Mouse IgG1
Applications: E, WB, IHC
Protein Family: Cytoskeleton Proteins
Pathway and Disease: Cell Motility, Immune System
Description:
Gelsolin is a calcium-regulated, actin-modulating protein that binds to the plus ends of actin monomers and filaments, preventing monomer exchange. Gelsolin promotes the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Defects in gelsolin are the cause of amyloidosis type 5 (AMYL5), also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition, and is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals, causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.
Alternate Names: Gelsolin, Actin-depolymerizing factor, ADF, Brevin, AGEL
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P06396
Antigen: Human plasma gelsolin.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.2% BSA with 0.09% sodium azide. Antibody was purified by anti-mouse IgG affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Han C et al. 2013. Exp Biol Med. 238(11): 1318-27. PMID 24047794.
Pathway and Disease: Cell Motility, Immune System
Description:
Gelsolin is a calcium-regulated, actin-modulating protein that binds to the plus ends of actin monomers and filaments, preventing monomer exchange. Gelsolin promotes the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Defects in gelsolin are the cause of amyloidosis type 5 (AMYL5), also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition, and is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals, causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.
Alternate Names: Gelsolin, Actin-depolymerizing factor, ADF, Brevin, AGEL
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P06396
Antigen: Human plasma gelsolin.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.2% BSA with 0.09% sodium azide. Antibody was purified by anti-mouse IgG affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Han C et al. 2013. Exp Biol Med. 238(11): 1318-27. PMID 24047794.
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