GenoType NTM-DR nontuberculous mycobacteria resistance PCR CE/IVD

The incidience of infections caused by nontuberculous mycobacteria (NTM) is increasing since several years. Therefore a target specific and effective therapy becomes more important. In the NTM-group especially the members of M. avium - and M. abcessus complexes are more important. Because of antibiotic resistence the infection caused by these mycobacteria are very difficult to treat. Therefore the treatment result is often very different.
Macrolides are an important component in the therapy of mycobacteria. Resistance against macrolides can significantly limit the therapy possibilities and limit the therapy success.
A possible resistance mechanism is mediated through mutations in the rrl-Gene. Another mechanism, that is found only in members of M. abcessus-Complex, is mediated through the erm(41)-Gene. This gene influences for some of it's subgroup the sensitivity for Clarithromycin. Therefore the detection of the erm(41) should be part of the molecular genetic resistance testing.
Aminoglycosides are often used for the treatment of nontuberculous mycobacteria. An aminoglycosides resistance is mediated exclusively through a mutation in the rrs/Gene.
Rapid what resistance For the management of NTM-infections rapid testing for the presence and type of resistance is important to enable an adequate and effective therapy.

GenoType NTM-DR enables the reliable detection of different clinically relevant NTM - including the differentation of M. intracellulare and M. chimaera. In the same test also resistance against macrlides and aminoglycosides are detected. Therefore with the help of GenoType NTM-DR you obtain valuable information for an adequate therapy.

Your benefits with GenoType NTM-DR

- Reliable results: GenoType NTM-DR detects and differentiates different nontuberculous mycobacteria (NTM) and in the same test resistance against macrolides and aminoglycosides is detected.
- Innovative: This test is based on a reliable technology and now makes it possible to both detect M. intracellulare and M. chimaera.
- Rapid results: Results with detailed information are available within a few hours in comparison to several weeks when using conventional methods.
- User friendly: The accepted DNA•STRIP-Technology allows manual or automated test processing. Therefore the implementation in your laboratory is flexible and uncomplicated.
- CE certified: No extensive validation studies are necessary.

Molecular genetic assay for identification of resistance to macrolides and aminoglycosides for nontuberculous mycobacteria (NTM)

Starting material:
liquid/solid culture samples

DNA Isolation:
GenoLyse®

Flyer
Mycobacteria
Early Diagnosis
Facts About Resistance
GenoType MTBDRsl Picture

Literature: