GFAP polyclonal, anti-human, mouse, rat
€378.00
In stock
SKU
250661
Catalog Nr.: 250661
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Cytoskeleton Proteins
Pathway and Disease: Neurodegenerative Disorders
Description:
Glial fibrillary acidic protein (GFAP), a class-III intermediate filament, is a cell-specific marker that distinguishes astrocytes from other glial cells during the development of the central nervous system (CNS). Defects in GFAP are a cause of Alexander disease, a rare disorder of the CNS described as leukoencephalopathy. GFAP is expressed in the cortex and hippocampus, and its expression decreases following acute and chronic corticosterone treatment.
Alternate Names: Glial fibrillary acidic protein, GFAP
Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500
Accession No.: P14136
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GFAP.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Cristofanilli M et al. 2014. Exp Neurol. 261: 620-32. PMID# 25111532.
[2] Ip J et al. 2011. Journal of Neuroinflammation. 8:124. PMID# 21943033.
Pathway and Disease: Neurodegenerative Disorders
Description:
Glial fibrillary acidic protein (GFAP), a class-III intermediate filament, is a cell-specific marker that distinguishes astrocytes from other glial cells during the development of the central nervous system (CNS). Defects in GFAP are a cause of Alexander disease, a rare disorder of the CNS described as leukoencephalopathy. GFAP is expressed in the cortex and hippocampus, and its expression decreases following acute and chronic corticosterone treatment.
Alternate Names: Glial fibrillary acidic protein, GFAP
Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500
Accession No.: P14136
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GFAP.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Cristofanilli M et al. 2014. Exp Neurol. 261: 620-32. PMID# 25111532.
[2] Ip J et al. 2011. Journal of Neuroinflammation. 8:124. PMID# 21943033.
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