GFI1 (clone 5D7), anti-human
€346.00
In stock
SKU
253057
Catalog Nr.: 253057
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB
Protein Family: Transcription factors
Pathway and Disease: Transcription
Description:
GFI1 (Growth factor independent protein 1) is a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. GFl1 is expressed in the hematopoietic and lymphoid system, sensory epithelia, lungs and CNS.
Alternate Names: Zinc finger protein Gfi-1, Growth factor independent protein 1, Zinc finger protein 163, ZNF163, GFI1
Application Notes: WB: 1:500-1:2000
Accession No.: Q99684
Antigen: Purified recombinant fragment of human GFI1 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Transcription
Description:
GFI1 (Growth factor independent protein 1) is a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. GFl1 is expressed in the hematopoietic and lymphoid system, sensory epithelia, lungs and CNS.
Alternate Names: Zinc finger protein Gfi-1, Growth factor independent protein 1, Zinc finger protein 163, ZNF163, GFI1
Application Notes: WB: 1:500-1:2000
Accession No.: Q99684
Antigen: Purified recombinant fragment of human GFI1 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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