GLRA1 polyclonal, anti-human

Protein Family: Receptors and Channels

Pathway and Disease: Signaling Molecules and Interaction, Nervous and Sensory Systems

Description:
The glycine receptor (GLAR1) is a neurotransmitter-gated ion channel. Binding of glycine to GLAR1 increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). Defects in GLRA1 are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. STHE is a genetically heterogeneous neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli.

Alternate Names: Glycine receptor subunit alpha-1, Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit, GLRA1, GlyR

Application Notes: E: 1:10,000-1:50,000; WB: 1:200-1:1,000; IHC: 1:100-1:500

Accession No.: P23415

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GLRA1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.