GRK5 polyclonal, anti-human, mouse, rat, chicken, guinea pig, monkey, enopus,

Protein Family: Enzymes, Protein Kinases, Receptors and Channels

Pathway and Disease: Immune System, Membrane Transport, Signaling Molecules and Interaction

Description:
G protein-coupled receptor kinase 5 (GRK5) is a serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptores (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. GRK5 is inhibited by calmodulin. Autophosphorylation play a critical role in the regulation of GRK5 kinase activity. GRK5 is overexpressed during heart failure.

Alternate Names: G protein-coupled receptor kinase 5, GRK5, GRK-5, GPRK5

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P34947

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GRK5.

Format: Each vial contains 0.1 ml IgG (1 mg/ml) in PBS pH 7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.