GSK3B (Ser9) polyclonal, anti-human, mouse, chicken, bovine, dog, zebrafish, xenopus, monkey
€440.00
In stock
SKU
252550
Catalog Nr.: 252550
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB
Protein Family: Enzymes, Protein Kinases
Pathway and Disease: Cancers, Cell Communication, Cell Growth and Death, Development and Behavior, Endocrine System, Immune System, Neurodegenerative Disorders, Signal Transduction
Description:
Glycogen synthase kinase-3 beta (GSK3b) participates in the Wnt signaling pathway. GSK3b is implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor Jun. GSK3b phosphorylates Jun at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Ser9 phosphorylation underlies the inhibition of GSK3b by insulin. This antibody is specific for the 46-kDa GSK-3b protein phosphorylated at Ser9, however a band at 51-kDa can also be detected due to high homology with GSK-3 alpha.
Alternate Names: Glycogen synthase kinase-3 beta, GSK-3 beta, GSK3B
Application Notes: E: 1:1,000; WB: 1:1,000
Accession No.: P18266
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser9 of rat glycogen synthase kinase 3 B (GSK3B).
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Cancers, Cell Communication, Cell Growth and Death, Development and Behavior, Endocrine System, Immune System, Neurodegenerative Disorders, Signal Transduction
Description:
Glycogen synthase kinase-3 beta (GSK3b) participates in the Wnt signaling pathway. GSK3b is implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor Jun. GSK3b phosphorylates Jun at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Ser9 phosphorylation underlies the inhibition of GSK3b by insulin. This antibody is specific for the 46-kDa GSK-3b protein phosphorylated at Ser9, however a band at 51-kDa can also be detected due to high homology with GSK-3 alpha.
Alternate Names: Glycogen synthase kinase-3 beta, GSK-3 beta, GSK3B
Application Notes: E: 1:1,000; WB: 1:1,000
Accession No.: P18266
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser9 of rat glycogen synthase kinase 3 B (GSK3B).
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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