hCG-beta (clone 5H4-E2), anti-human

Source:
A BALB/c mouse was hCG beta, conjugated to various carrier proteins.
Fusion partner: SP-2/0-Ag14.

Specifications:
5H4-E2 reacts with hCG beta chain, which is specific for hCG. The alpha chain is identical among hCG, TSH, FSH and LH. While hCG is secreted in large quantities by normal trophoblasts, it is present only in trace amounts in non-pregnant urineand sera but rises sharply during pregnancy. Besides trophoblastic tumors e.g. choriocarcinoma, large cell carcinoma, adenocarcinoma and squamous cell carcinoma of the lung are also positive in 90%, 60% and 20% of cases respectively. In hCG producing tumors, including also certain testicular and embryonic carcinomas, the beta chain is produced in higher quantities than the alpha or dimeric chains. hCG expression by non-trophoblastic tumors may indicate aggressive behavior.

Species reactivity:
Positive: human.

Applications:
Pregnancy and oncology.
Frozen sections: +
Paraffin sections: +

Positive control: JAR or TT Cells. Placenta.

References:
- McDonald EA et. al. Endocrinology150:4358-65 (2009)