HCLS1 polyclonal, anti-human, mouse, rat

Protein Family: Protein Kinases

Pathway and Disease: Cell Communication,Infectious Diseases

Description:
Hematopoietic lineage cell-specific protein (HCLS1) is a substrate of the antigen receptor-coupled tyrosine kinase. HCLS1 plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. HCLS1 is involved in the regulation of gene expression. HCLS1 associates with the SH2 and SH3 domains of LCK. Binding to the LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation.

Alternate Names: Hematopoietic lineage cell-specific protein, Hematopoietic cell-specific LYN substrate 1, LckBP1, p75, HCLS1, HS1

Application Notes: E: 1:10,000-1:50,000; WB: 1:200-1:1,000; IHC: 1:50-1:200

Accession No.: P14317

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human HCLS1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.