HDAC3 (clone 3A7B5), anti-human
€443.00
In stock
SKU
252812
Catalog Nr.: 252812
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB, IHC
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB, IHC
Protein Family: Enzymes
Pathway and Disease: Signal Transduction, Cancers, Cell Growth and Death, Transcription
Description:
HDAC3 (Histone deacetylase 3) is a histone deacetylase protein. Histones play a critical role in transcriptional regulation, cell cycle progression and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Alternate Names: Histone deacetylase 3, HD3, RPD3-2, SMAP45, HDAC3
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000;
Accession No.: O15379
Antigen: Purified recombinant fragment of HDAC3(aa224-428) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Signal Transduction, Cancers, Cell Growth and Death, Transcription
Description:
HDAC3 (Histone deacetylase 3) is a histone deacetylase protein. Histones play a critical role in transcriptional regulation, cell cycle progression and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Alternate Names: Histone deacetylase 3, HD3, RPD3-2, SMAP45, HDAC3
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000;
Accession No.: O15379
Antigen: Purified recombinant fragment of HDAC3(aa224-428) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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