Hepatitis C Virus (HCV) NS5B (blocking) (clone 5B-12B7), anti-virus
€284.00
In stock
SKU
ARP-23-B0003
Catalog Number: 23-B0003
Size: 25 µg
Isotype: Mouse IgG2a
Size: 25 µg
Isotype: Mouse IgG2a
Decription:
The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.
Synonyms: Nonstructural Protein 5B
Clone: 5B-12B7
Isotype: Mouse IgG2a
Immunogen: Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
Reactivity: HCV
Specificity: Recognizes HCV NS5B from HCV genotype 1 (epitope mapped to NS5B aa 139-392). Does not react with genotype 2.
Form: Purified, in PBS containing 0.02% sodium azide.
Applications:
Immunocytochemistry: (1:100)
Immunoprecipitation
Functional Application: Blocks the RNA-dependent RNA polymerase activity in vitro. Note: Not suitable for Western blot. Use anti-NS5B (HCV) mAb (5B-3B1) (Prod. No. AG- 20B-0002).
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 1mg/ml
Storage: 2-8C immediate use, or -20C (aliquote)
The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.
Synonyms: Nonstructural Protein 5B
Clone: 5B-12B7
Isotype: Mouse IgG2a
Immunogen: Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
Reactivity: HCV
Specificity: Recognizes HCV NS5B from HCV genotype 1 (epitope mapped to NS5B aa 139-392). Does not react with genotype 2.
Form: Purified, in PBS containing 0.02% sodium azide.
Applications:
Immunocytochemistry: (1:100)
Immunoprecipitation
Functional Application: Blocks the RNA-dependent RNA polymerase activity in vitro. Note: Not suitable for Western blot. Use anti-NS5B (HCV) mAb (5B-3B1) (Prod. No. AG- 20B-0002).
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 1mg/ml
Storage: 2-8C immediate use, or -20C (aliquote)
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