HER-2 (clone 9B9D8), anti-human
€319.00
In stock
SKU
252700
Catalog Nr.: 252700
Size: 0.1 ml
Isotype: Mouse IgG2b
Applications: E, WB, IHC
Size: 0.1 ml
Isotype: Mouse IgG2b
Applications: E, WB, IHC
Protein Family: Enzymes, Receptors and Channels, Protein Kinases
Pathway and Disease: Cancers, Development and Behavior, Cell Communication, Signaling Molecules and Interaction
Description:
C-erbB-2 (HER2) is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. HER2 has no ligand binding domain, therefore cannot bind growth factors. However, HER2 does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.
Alternate Names: Receptor tyrosine protein kinase erbB2, p185erbB2, C-erbB-2, Neu proto-oncogene, Tyrosine kinase-type cell surface receptor HER2, MLN 19, ERBB2, HER2, NEU, NGL
Application Notes: E: 1:5000-1:10000; WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: P04626
Antigen: Purified recombinant fragment of human ERBB2 (aa750-987) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cancers, Development and Behavior, Cell Communication, Signaling Molecules and Interaction
Description:
C-erbB-2 (HER2) is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. HER2 has no ligand binding domain, therefore cannot bind growth factors. However, HER2 does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.
Alternate Names: Receptor tyrosine protein kinase erbB2, p185erbB2, C-erbB-2, Neu proto-oncogene, Tyrosine kinase-type cell surface receptor HER2, MLN 19, ERBB2, HER2, NEU, NGL
Application Notes: E: 1:5000-1:10000; WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: P04626
Antigen: Purified recombinant fragment of human ERBB2 (aa750-987) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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