HERG polyclonal, anti-human, mouse, rat

Protein Family: Receptors and Channels

Pathway and Disease: Nervous and Sensory Systems

Description:
Potassium voltage-gated channel subfamily H member 2 (HERG) is the pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. The HERG channel properties are modulated by cAMP and subunit assembly. HERG mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1. Defects in HERG are the cause of long QT syndrome type 2 (LQT2). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress.

Alternate Names: Potassium voltage-gated channel subfamily H member 2, Voltage-gated potassium channel subunit Kv11.1, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, Eag-related protein 1, ERG-1, hERG-1, hERG1, H-ERG, Eag homolog, KCNH2, ERG, ERG1, HERG

Application Notes: E: 1:1,000-1:10,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q12809

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human HERG.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by immunogen-affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.