HES-1 polyclonal, anti-human, mouse, rat

Protein Family: Transcription Factors

Pathway and Disease: Metabolic Disorders, Signal Transduction, Transcription

Description:
Transcription factor HES-1 (HES-1) is a transcriptional repressor of genes that require a bHLH protein for their transcription. HES-1 acts as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. HES-1 binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity.

Alternate Names: Transcription factor HES-1, Hairy and enhancer of split 1, Hairy-like protein, hHL, Hairy homolog, Class B basic helix-loop-helix protein 39, bHLHb39, HES1, BHLHB39, HL, HRY

Application Notes: E: 1:10,000-1:50,000; WB: 1:100-1:1,000; IHC: 1:50-1:500

Accession No.: Q14469

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human HES-1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.5% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.