HHV-8 VIL-6 polyclonal, anti-virus
€378.00
In stock
SKU
251352
Catalog Nr.: 251352
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Cytokines
Pathway and Disease: Signaling Molecules and Interaction, Signal Transduction, Infectious Diseases
Description:
Human herpesvirus 8 (HHV-8 or KSHV, Kaposi's sarcoma-associated herpesvirus) has been associated with classical, endemic (African), and AIDS-related Kaposi's sarcoma (KS), body cavity-based primary effusion lymphomas, and multicentric Castleman's disease (MCD). KSHV encodes more than 85 protein-coding genes. ORF K2 encodes a viral form of interleukin-6 (vIL-6), a cytokine that promotes the growth of KS and myeloma cells and is found at elevated levels in MCD lesions and patient sera. vIL-6 shares 25% amino-acid identity with human cellular IL-6.
Alternate Names: HHV-8 VIL-6, HHV8 ORF K2, vIL-6, ORF K2, Human herpesvirus 8, Putative interleukin 6, Kaposi's sarcoma-associated herpesvirus VIL-6
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: Q76SK3; O40918
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region ORF K2 from HHV-8 VIL-6.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Wu J et al. 2014. PLoS ONE. 9(3):e93478. PMID#24675762.
[2] Venkataraman G et al. 2013. American Journal of Clinical Pathology. 139: 651-661. PMID# 23596117
Pathway and Disease: Signaling Molecules and Interaction, Signal Transduction, Infectious Diseases
Description:
Human herpesvirus 8 (HHV-8 or KSHV, Kaposi's sarcoma-associated herpesvirus) has been associated with classical, endemic (African), and AIDS-related Kaposi's sarcoma (KS), body cavity-based primary effusion lymphomas, and multicentric Castleman's disease (MCD). KSHV encodes more than 85 protein-coding genes. ORF K2 encodes a viral form of interleukin-6 (vIL-6), a cytokine that promotes the growth of KS and myeloma cells and is found at elevated levels in MCD lesions and patient sera. vIL-6 shares 25% amino-acid identity with human cellular IL-6.
Alternate Names: HHV-8 VIL-6, HHV8 ORF K2, vIL-6, ORF K2, Human herpesvirus 8, Putative interleukin 6, Kaposi's sarcoma-associated herpesvirus VIL-6
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: Q76SK3; O40918
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region ORF K2 from HHV-8 VIL-6.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Wu J et al. 2014. PLoS ONE. 9(3):e93478. PMID#24675762.
[2] Venkataraman G et al. 2013. American Journal of Clinical Pathology. 139: 651-661. PMID# 23596117
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