HMGB1 (clone ), anti-human, mouse, rat

Background:
High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Research suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture, including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, ATF-2, c-Jun and members of the NFκB family to activate transcription.

Alternative Name:
High mobility group protein B1, High mobility group protein 1, HMG-1, HMGB1, HMG1

Application Dilution: WB: 1:1000-1:5000, IHC/ICC/IF: 1:50-1:200, FC: 1:10-1:100

Specificity: This antibody detects endogenous levels of HMGB1 and does not cross-react with related proteins.

Immunogen:
Recombinant antibody.

MW: ~ 25 kDa

Swis Prot.: P09429

Purification & Purity:
Protein A affinity purified

Format:
Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.