HRas polyclonal, anti-human, mouse, rat

Protein Family: GTP-binding Proteins, Transporters

Pathway and Disease: Signal Transduction, Cell Motility, Cell Communication, Immune System, Endocrine System, Nervous and Sensory Systems, Development and Behavior, Cancers

Description:
GTPase HRas (HRas) binds GDP/GTP and possess intrinsic GTPase activity. HRas alternates between an inactive form bound to GDP and an active form bound to GTP. HRas is activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Defects in HRAS are the cause of Costello syndrome (COSTS), also known as faciocutaneoskeletal syndrome. Costello syndrome is a rare condition characterized by prenatally increased growth, postnatal growth deficiency, mental retardation, distinctive facial appearance, cardiovascular abnormalities (typically pulmonic stenosis, hypertrophic cardiomyopathy and/or atrial tachycardia), tumor predisposition, and skin and musculoskeletal abnormalities.

Alternate Names: HRas, GTPase HRas, Transforming protein p21, p21ras, H-Ras-1, c-H-ras, Ha-Ras

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P01112

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human HRas.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.