HSP-60 polyclonal, anti-human, mouse, rat
€378.00
In stock
SKU
250700
Catalog Nr.: 250700
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Chaperones and Folding Catalysts
Pathway and Disease: Folding, Sorting and Degradation, Metabolic Disorders, Neurodegenerative Disorders
Description:
Heat shock protein 60 (HSP-60) is implicated in mitochondrial protein import and macromolecular assembly. HSP-60 facilitates the correct folding of imported proteins. HSP-60 also prevents misfolding and promotes refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. Defects in HSP-60 are a cause of spastic paraplegia autosomal dominant type 13 (SPG13), a degenerative spinal cord disorder. Defects in HSP-60 are the cause of leukodystrophy hypomyelinating type 4 (HLD4 or MitCHAP-60 disease).
Alternate Names: 60 kDa heat shock protein, mitochondrial, Heat shock protein 60, HSP-60, Hsp60, 60 kDa chaperonin, Chaperonin 60, CPN60, Mitochondrial matrix protein P1, P60 lymphocyte protein, HuCHA60, HSPD1, HSP60
Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500
Accession No.: P10809
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human HSP-60.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Chowdhury D et al. 2013. Journal of Translational Medicine. doi: 10.1186/147958876-11-130. PMID# 21839735.
Pathway and Disease: Folding, Sorting and Degradation, Metabolic Disorders, Neurodegenerative Disorders
Description:
Heat shock protein 60 (HSP-60) is implicated in mitochondrial protein import and macromolecular assembly. HSP-60 facilitates the correct folding of imported proteins. HSP-60 also prevents misfolding and promotes refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. Defects in HSP-60 are a cause of spastic paraplegia autosomal dominant type 13 (SPG13), a degenerative spinal cord disorder. Defects in HSP-60 are the cause of leukodystrophy hypomyelinating type 4 (HLD4 or MitCHAP-60 disease).
Alternate Names: 60 kDa heat shock protein, mitochondrial, Heat shock protein 60, HSP-60, Hsp60, 60 kDa chaperonin, Chaperonin 60, CPN60, Mitochondrial matrix protein P1, P60 lymphocyte protein, HuCHA60, HSPD1, HSP60
Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500
Accession No.: P10809
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human HSP-60.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Chowdhury D et al. 2013. Journal of Translational Medicine. doi: 10.1186/147958876-11-130. PMID# 21839735.
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