Human CD274 Capture Beads for Flow Detection RUO

INTRODUCTION
Exosomes are small extracellular vesicles that are released from cells upon fusion of an intermediate endocytic compartment, the multivesicular body (MVB) 1, with the plasma membrane. They are thought to provide a means of intercellular communication (2,3) and of transmission of macromolecules between cells allowing the spread of proteins, lipids, mRNA, miRNA and DNA and as contributing factors in the development of several diseases. Exosomes can also modulate cancer microenvironment (4) and the immune response (5,6).

PRODUCT DESCRIPTION
The product consists of a simple bead population, coated with a capture antibody for isolation/detection of exosomes.
• Tested application: Flow Cytometry (7,8).
• Species reactivity: Human / Mouse (MO63CB-25)
• Storage buffer: aqueous buffered solution containing protein stabilizer and 0.09% sodium azide (NaN3).• Recommended usage: Capture Beads are intended for the immunoisolation (immunomagnetic or FACS) and Flow Cytometry analysis of pre-enriched human exosomes from biofluids (plasma, urine) or cell culture media.
• Presentation: Liquid