Hyaluronidase-1 polyclonal, anti-human, mouse, rat

Protein Family: Enzymes, Glycan Binding Proteins

Pathway and Disease: Glycan Biosynthesis and Metabolism, Membrane Transport, Infectious Diseases

Description:
Hyaluronidase-1 plays a role in promoting tumor progression. Hyaluronidase-1 blocks TGFB1-enhanced cell growth. Defects in hyaluronidase-1 are the cause of mucopolysaccharidosis type 9, also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement.

Alternate Names: Hyaluronidase-1, Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, LUCA1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q76HN1

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of rat hyaluronidase-1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.