ICAD polyclonal, anti-mouse, rat

Protein Family: Enzymes

Pathway and Disease: Cell Growth and Death

Description:
Inhibitor of CAD (ICAD, DNA fragmentation factor 45 kDa subunit, DFF-45 is an inhibitor of the caspase-activated DNase. Caspase-activated deoxyribonuclease (CAD) is also designated as DNA fragmentation factor 40 kDa subunit (DFF-40) and caspase-activated Dnase. CAD is a nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. ICAD is a heterodimer of DFFA and DFFB. Caspase-3 cleaves ICAD at 2 sites to generate an active factor.

Alternate Names: ICAD, Inhibitor of Caspase-Activated Dnase, DNA fragmentation factor subunit alpha, DNA fragmentation factor 45 kDa subunit, DFF-45, Inhibitor of CAD, DFFA, DFF1, DFF45

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: O00273

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of mouse ICAD.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.