ICSBP polyclonal, anti-human
€347.00
In stock
SKU
252105
Catalog Nr.: 252105
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB
Protein Family: Transcription Factors
Pathway and Disease: Transcription, Immune System
Description:
Interferon regulatory factor 8 (ICSBP) specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). ICSBP plays a negative regulatory role in cells of the immune system. ICSBP is ubiquitinated by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation. This leads to the enhanced transcriptional activity of target cytokine genes.
Alternate Names: Interferon regulatory factor 8, IRF-8, Interferon consensus sequence-binding protein, ICSBP, IRF8, ICSBP1
Application Notes: E: 1:10,000-1:50,000; WB: 1:200-1:1,000
Accession No.: Q02556
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ICSBP.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Transcription, Immune System
Description:
Interferon regulatory factor 8 (ICSBP) specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). ICSBP plays a negative regulatory role in cells of the immune system. ICSBP is ubiquitinated by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation. This leads to the enhanced transcriptional activity of target cytokine genes.
Alternate Names: Interferon regulatory factor 8, IRF-8, Interferon consensus sequence-binding protein, ICSBP, IRF8, ICSBP1
Application Notes: E: 1:10,000-1:50,000; WB: 1:200-1:1,000
Accession No.: Q02556
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ICSBP.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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