IDH2 polyclonal, anti-human, mouse, rat
€396.00
In stock
SKU
254307
Catalog Nr.: 254307
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, IF
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, IF
Protein Family: Enzymes
Pathway and Disease: Amino Acid Metabolism, Carbohydrate Metabolism, Energy Metabolism, Metabolic Disorders
Description:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Two NADP(+)-dependent isocitrate dehydrogenases have been found as homodimer: IDH1 is predominantly cytosolic and peroxisomal and IDH2 is mitochondrial. Both IDH1 and IDH2 play significant roles in the tricarboxylic acid cycle (TCA), and defects in IDH1 as well as IDH2 have been implicated in the development of glioma as well as other malignancies.
Alternate Names: IDH2, Mitochondrial NADP-isocitrate dehydrogenase, IDH, IDP, IDHM, IDPM, ICD-M, mNADP-IDH
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IF: 1:50-1:200
Accession No.: NP_002159
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IDH2.
Format: Each vial contains 0.1 mg IgG (1 mg/ml) in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Amino Acid Metabolism, Carbohydrate Metabolism, Energy Metabolism, Metabolic Disorders
Description:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Two NADP(+)-dependent isocitrate dehydrogenases have been found as homodimer: IDH1 is predominantly cytosolic and peroxisomal and IDH2 is mitochondrial. Both IDH1 and IDH2 play significant roles in the tricarboxylic acid cycle (TCA), and defects in IDH1 as well as IDH2 have been implicated in the development of glioma as well as other malignancies.
Alternate Names: IDH2, Mitochondrial NADP-isocitrate dehydrogenase, IDH, IDP, IDHM, IDPM, ICD-M, mNADP-IDH
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IF: 1:50-1:200
Accession No.: NP_002159
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IDH2.
Format: Each vial contains 0.1 mg IgG (1 mg/ml) in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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