IFN-alpha 1 (clone 2-52), anti-human

IFN-alpha 1 (clone 2-52), anti-human

€195.00
In stock
SKU
EMC0336-01
Catalog Number: EMC0336-01
Size: 100 μg
Isotype: mouse IgG1-k
Applications: ELISA, IHC/F, Pair, WB
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Source:
A BALB/c mouse was immunized with E. coli derived recombinant human IFNα1.
Fusion partner: NS-0.

Specifications:
The alpha interferons are involved in virus resistance in target cells for these viruses. They are known to block cell proliferation and to regulate MHC class I antigen expression. The IFNαfamily has over 20 genes and pseudogenes in two families (I and II), one with a mature length of 166aa and one of 172aa. Cells producing IFNαare lymphocytes, monocytes, macrophages and cell lines such as Namalwa and KGI. Bioassays forIFNαinclude cytopathic effect blocking, by viruses such as VSV, SFV and BMCV, on their target cells. A number of receptors for IFNαare now known and seem to be expressed on most cell types. 2-52 Is specific for human IFNα1 and does not cross react with human IFNα2.

Species reactivity:
Positive: human.

Applications:
2-52 Can be used for the detection of human IFNα1 in ELISA and Western blot. It can be paired with IFNα1 mAb 2-48 to form an EIA to measure IFNα1.
ELISA: +
Frozen sections: +
Pair: +
Western blot: +

Positive control: Human IFNα1, Namalwa and KGI cells.

References:
- Kontsek, P. et al., Mol Immunol. 29: 863-870 (1992).
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