IFNAR1 (Ser535/539) polyclonal, anti-human, mouse, rat, bovine, dog, sheep, monkey
€405.00
In stock
SKU
252551
Catalog Nr.: 252551
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 ml
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Receptors and Channels
Pathway and Disease: Signal Transduction, Signaling Molecules and Interaction, Development and Behavior, Infectious Diseases, Immune System
Description:
Interferon-a Receptor, Type I, Subunit I (IFNAR1) associates with IFNAR2 to form the type I interferon receptor. This interferon receptor is a receceptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Down regulation of IFNAR1 is influenced by phosphorylation of Serine 535 and 539.
Alternate Names: Interferon alpha/beta receptor 1, FN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1 Type I interferon receptor 1, IFNAR1, IFNAR
Application Notes: MW of phosphorylated IFNAR1 is observed at 110-130 kDa depending on cell lines due to different glycosylation patterns. E: 1:1,000; WB: 1:1,000; IHC: 1:1,000
Accession No.: P17181
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser535/539 of human interferon-a receptor, type I, subunit I.
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signal Transduction, Signaling Molecules and Interaction, Development and Behavior, Infectious Diseases, Immune System
Description:
Interferon-a Receptor, Type I, Subunit I (IFNAR1) associates with IFNAR2 to form the type I interferon receptor. This interferon receptor is a receceptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Down regulation of IFNAR1 is influenced by phosphorylation of Serine 535 and 539.
Alternate Names: Interferon alpha/beta receptor 1, FN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1 Type I interferon receptor 1, IFNAR1, IFNAR
Application Notes: MW of phosphorylated IFNAR1 is observed at 110-130 kDa depending on cell lines due to different glycosylation patterns. E: 1:1,000; WB: 1:1,000; IHC: 1:1,000
Accession No.: P17181
Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser535/539 of human interferon-a receptor, type I, subunit I.
Format: Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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