IgA2 (clone SAA2) PE, anti-human RUO

Human IgA occurs in multiple molecular forms (polymeric and monomeric) and two subclasses which show differential distribution between the mucosal and circulatory compartments of the immune system. In humans, 85–90% of IgA antibodies are found in body secretions such us saliva, tears, breast milk; gastrointestinal mucous membranes, urogenital and respiratory tracts and prostatic fluid, among others. The other 10-15% of IgA antibodies are found in blood as monomeric, IgA1, and polymeric forms IgA2. IgA1 is present 5 times more than IgA2.

Recomended usage
Immunostep’s anti-human IgA2, clone SAA2, is a monoclonal antibody intended for the identification of cells expressing IgA2 protein in peripheral blood using a compatible flow cytometer. This reagent is effective for direct immunofluorescence staining of human tissue for flow cytometric analysis using 1 test for 10^6 cells or 100 ml of sample. Anti-IgA2 should be used with wash steps before reagent addition or with ficoll gradient separation to remove Immunoglobulins from serum.