IGF2 polyclonal, anti-human, mouse, rat

Protein Family: Cytokines

Pathway and Disease: Cancers, Cell Growth and Death, Cell Communication, Nervous and Sensory Systems, Signal Transduction

Description:
Insulin-like Growth Factors IGF1 and IGF2 share 76% sequence identity and are 50% related to pro-insulin. They are non-glycosylated, single-chain proteins of 70 and 76 amino acids in length respectively. IGF1 functions as an autocrine regulator of growth in various tissues, whereas IGF2 is found in placenta. Defects in IGF1 are the cause of insulin-like growth factor I deficiency defined by growth retardation, sensorineural deafness and mental retardation.

Alternate Names: Insulin-like growth factor II, IGF-II, somatomedin A, IGF2

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: P01344

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IGF2.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] Malempati S et al. 2012. Journal of Clinical Oncology 30(3) 256-262. PMID# 22184397.
[2] Matsumoto A et al. 2011. Biomedical And Life Sciences. In Vitro Cellular & developmental Biology-Animal. 47(9): 675-680. PMID# 21959847