IL-15 polyclonal, anti-human, mouse, rat

Protein Family: Cytokines

Pathway and Disease: Immune System, Infectious Diseases, Signal Transduction, Signaling Molecules and Interaction

Description:
Interleukin-15 (IL-15) is a 114 amino acids cytokine that regulates T and natural killer cell activation and proliferation. Human IL-15 shares approximately 97% and 73% amino acid sequence identity with simian and mouse IL-15, respectively. IL-15 was initially isolated from the simian kidney epithelial cell line CV1/EBNA. The cytokines IL-15 and IL-2 share many biological properties and stimulatory activities (T, B, and NK cells). Both IL-15 and IL-2 stimulate mouse CTLL2 cells. In activated peripheral blood T lymphocytes, IL-2 is highly expressed but the expression of IL-15 is not detectable. There is no sequence homology between IL-15 and IL-2, though IL-15 competes for binding sites with IL-2. Both stimulate the growth of cells through the IL-2 receptor. IL-15 mRNA is expressed in many cell types and tissues including adherent peripheral blood mononuclear cells, fibroblasts, and epithelial cells, monocytes, placenta, and skeletal muscle.

Alternate Names: IL-15, IL15, Interleukin-15

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: P40933

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human IL-15.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1 mg/ml BSA, 25% glycerol with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.