IL-17F human active recombinant protein
€295.00
In stock
SKU
600139
Protein Family: Cytokines
Pathway and Disease: Immune System, Signal Transduction, Signaling Molecules and Interaction
Alternate Names: Interleukin-17F, IL-17F, Cytokine ML-1, IL17FDescription:
Interleukin-17F (IL-17F) is one of six members of the IL-17 family (IL-17A-F) secreted by activated CD4+ T cells and monocytes. Similar to IL-17A, IL-17F binds to the IL-17RC receptor and promotes the production of IL-6, IL-8, G-CSF and increases cartilage matrix turnover rates. IL-17F is also thought to inhibit angiogenesis and induce endothelial cells to produce IL-2, MCP-1 and TGF-beta1. Recombinant Human IL-17F is a non-glycosylated protein consisting of two 134 amino acid polypeptide chains linked by disulfide bridges with a MW of 30 kDa. The recombinant protein corresponds to full-length IL-17F and has cytokine production activity on mouse cells.
Source: E. coli. Endotoxin level as measured by LAL is <0.1 ng/ug or <1 EU/ug.
Applications: E, WB
Application Notes:
Human IL-17F is fully biologically active when compared to standard. The ED50 as determined by the dose-dependent production of IL-6 in cultured mouse NIH-3T3 fibroblast cells is typically 8-40 ng/ml.
Accession No.: Q96PD4
MW: 30062 Da
Sequence:
MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ
Purity:
Purity Approximately 97% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm. Quantitation on SDS-PAGE against a known standard.
Format:
Each vial contains 25 ug protein lyophilized in 10 mM sodium citrate pH3.0. Reconstitute with 0.25 ml sterile deionized water for a final concentration of 0.1 mg/ml.
Storage: Store at -20°C. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. We recommend to add a carrier protein (0.1% HSA or BSA) for long term storage.
Pathway and Disease: Immune System, Signal Transduction, Signaling Molecules and Interaction
Alternate Names: Interleukin-17F, IL-17F, Cytokine ML-1, IL17FDescription:
Interleukin-17F (IL-17F) is one of six members of the IL-17 family (IL-17A-F) secreted by activated CD4+ T cells and monocytes. Similar to IL-17A, IL-17F binds to the IL-17RC receptor and promotes the production of IL-6, IL-8, G-CSF and increases cartilage matrix turnover rates. IL-17F is also thought to inhibit angiogenesis and induce endothelial cells to produce IL-2, MCP-1 and TGF-beta1. Recombinant Human IL-17F is a non-glycosylated protein consisting of two 134 amino acid polypeptide chains linked by disulfide bridges with a MW of 30 kDa. The recombinant protein corresponds to full-length IL-17F and has cytokine production activity on mouse cells.
Source: E. coli. Endotoxin level as measured by LAL is <0.1 ng/ug or <1 EU/ug.
Applications: E, WB
Application Notes:
Human IL-17F is fully biologically active when compared to standard. The ED50 as determined by the dose-dependent production of IL-6 in cultured mouse NIH-3T3 fibroblast cells is typically 8-40 ng/ml.
Accession No.: Q96PD4
MW: 30062 Da
Sequence:
MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ
Purity:
Purity Approximately 97% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm. Quantitation on SDS-PAGE against a known standard.
Format:
Each vial contains 25 ug protein lyophilized in 10 mM sodium citrate pH3.0. Reconstitute with 0.25 ml sterile deionized water for a final concentration of 0.1 mg/ml.
Storage: Store at -20°C. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. We recommend to add a carrier protein (0.1% HSA or BSA) for long term storage.
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