IL-23 human GMP recombinant protein

Backgroud: Interleukin-23 (IL-23) is a heterodimeric cytokine that belongs to the IL-12 cytokine family. It is composed of two subunits, p19 and p40, with the p40 subunit being shared with IL-12. IL-23 is primarily secreted by activated macrophages and dendritic cells located in peripheral tissues such as skin, intestinal mucosa, and lung. This cytokine plays a crucial role in the development and maintenance of autoimmune inflammation, particularly through its ability to induce IL-17 production, which is a unique role compared to IL-12.

Synonyms: SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2

Construction: Recombinant Human IL-23 is produced by our Mammalian cell expression system and the target gene encoding Ile23-Ser328&Arg23-Pro189 is expressed.

Purity: Greater than 95% as determined by reducing SDS-PAGE

Endotoxin: ≤10 EU/mg

Activity: The ED50 for this effect is ＜0.5 μg/mL.

Accession No.: P29460(P40), AAG37232(P19)

Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.