IL-6R polyclonal, anti-human

Protein Family: Cytokines, Cellular Antigens, Receptors and Channels

Pathway and Disease: Signaling Molecules and Interaction, Signal Transduction, Immune System

Description:
Interleukin-6R binds to IL6 with low affinity, but does not transduce a signal. A soluble IL-6R is produced by both naive and memory CD4 T cells upon TCR activation. The production of IL6-R by activated CD4 T cells is mediated by shedding of the membrane-bound IL-6R, and this process correlates with the expression of the metalloproteinase ADAM17 in these cells. In contrast to CD4 T cells, CD8 T cells do not express ADAM17 and their production of IL-6R is negligible. Thus, during an immune response CD4 T cells are an important source of IL-6R. Production of IL-6R by autoreactive CD4 T cells may contribute to their role in the development of autoimmune disease by conferring IL-6-responsiveness to cells lacking IL-6R such as synoviocytes.

Alternate Names: Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA , IL-6R 1, Membrane glycoprotein 80, gp80, CD126

Application Notes: E: 1:1,000-1:10,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P08887

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human IL-6R.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by immunogen-affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.