CD121a (IL1R1) polyclonal, anti-human
€388.00
In stock
SKU
BS7818
Background:
Three structurally related ligands for IL-1Rs have been described. These include two agonists, IL-1α and IL-1β, and a specific receptor antagonist, IL-1Rα. Among the activities regulated by IL-1 are fever, acute phase responses, degradation of connective tissue and immunostimulatory activities. The IL-1Rα molecule also binds specifically to IL-1Rs, but fails to initiate intracellular responses. Two distinct IL-1Rs have been identified, each of which belongs to the Ig superfamily and is widely expressed in a broad range of cells and tissues. Although many cell types co-express type I and type II receptors, there is no evidence that these constitute subunits of a single complex. The type II receptor has a short 29 amino acid cytoplasmic domain that does not seem sufficient for signaling while in fact there is considerable evidence arguing that IL-1 signals exclusively through the type I IL-1R.
Alternative Name:
Antigen CD121a, CD121 antigen-like family member A, CD121A, CD121a antigen, D2S1473, IL 1, IL 1R 1, IL 1R alpha, IL 1RT1, IL-1R-1, IL-1R-alpha, IL-1RT-1, IL-1RT1, IL1 inhibitor, IL1R, IL1R1, IL1R1_HUMAN, IL1RA, IL1RN,IL1RT1, Interleukin 1 receptor alpha type 1, Interleukin 1 receptor antagonist protein (IRAP), Interleukin 1 receptor type I, Interleukin receptor 1, Interleukin-1 receptor alpha, Interleukin-1 receptor type 1, Interleukin-1 receptor type I, P80,
Application Dilution: WB: 1:500 - 1:2000
Specificity: IL1R1 polyclonal antibody detects endogenous levels of IL1R1 protein.
Immunogen:
Recombinant full length Human IL1R1.
MW: ~ 75, 80 kDa
Swis Prot.: P14778
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Three structurally related ligands for IL-1Rs have been described. These include two agonists, IL-1α and IL-1β, and a specific receptor antagonist, IL-1Rα. Among the activities regulated by IL-1 are fever, acute phase responses, degradation of connective tissue and immunostimulatory activities. The IL-1Rα molecule also binds specifically to IL-1Rs, but fails to initiate intracellular responses. Two distinct IL-1Rs have been identified, each of which belongs to the Ig superfamily and is widely expressed in a broad range of cells and tissues. Although many cell types co-express type I and type II receptors, there is no evidence that these constitute subunits of a single complex. The type II receptor has a short 29 amino acid cytoplasmic domain that does not seem sufficient for signaling while in fact there is considerable evidence arguing that IL-1 signals exclusively through the type I IL-1R.
Alternative Name:
Antigen CD121a, CD121 antigen-like family member A, CD121A, CD121a antigen, D2S1473, IL 1, IL 1R 1, IL 1R alpha, IL 1RT1, IL-1R-1, IL-1R-alpha, IL-1RT-1, IL-1RT1, IL1 inhibitor, IL1R, IL1R1, IL1R1_HUMAN, IL1RA, IL1RN,IL1RT1, Interleukin 1 receptor alpha type 1, Interleukin 1 receptor antagonist protein (IRAP), Interleukin 1 receptor type I, Interleukin receptor 1, Interleukin-1 receptor alpha, Interleukin-1 receptor type 1, Interleukin-1 receptor type I, P80,
Application Dilution: WB: 1:500 - 1:2000
Specificity: IL1R1 polyclonal antibody detects endogenous levels of IL1R1 protein.
Immunogen:
Recombinant full length Human IL1R1.
MW: ~ 75, 80 kDa
Swis Prot.: P14778
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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