CD126 (IL6R) polyclonal, anti-human
€388.00
In stock
SKU
BS7203
Background:
IL-6 activates intracellular signaling through binding a receptor consisting of a ligand-binding protein (IL-6Rα) and a second protein. IL-6 first binds to IL-6Rα (also known as gp80), which subsequently associates with a gp130 dimer. The active signaling complex consists of, at minimum, IL-6, IL-6Rα and a dimer of two gp130 proteins that are linked by a disulfide bond. A soluble form of IL-6Rα, namely sIL-6Rα, is generated by proteolytic cleavage of the membrane-bound precursor and can function as an agonistic molecule that can actively participate in cell-to-cell signaling. The second subunit of the IL-6 complex, gp130, also functions as a component of several additional receptor complexes, including leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11. LIF binds to the LIF receptor with low affinity and to a complex of the LIF receptor and gp130 with high affinity, while OSM appears to bind to gp130 with low affinity and to a complex of gp130 and the LIF receptor with high affinity.
Alternative Name:
CD 126, CD126, CD126 antigen, gp80, IL 6R 1, IL 6R alpha, IL 6R, IL-6 receptor alpha chain, IL-6 receptor subunit alpha, IL-6R 1, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL6Q, Il6r, IL6RA, IL6RA_HUMAN, IL6RQ, Interleukin 6 receptor, interleukin 6 receptor, alpha, Interleukin-6 receptor subunit alpha, Membrane glycoprotein 80, MGC30256,
Application Dilution: WB: 1:500~1:2000
Specificity: IL6R polyclonal antibody detects endogenous levels of IL6R protein.
Immunogen:
Recombinant full length Human IL6R.
MW: ~ 52 kDa
Swis Prot.: P08887
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
IL-6 activates intracellular signaling through binding a receptor consisting of a ligand-binding protein (IL-6Rα) and a second protein. IL-6 first binds to IL-6Rα (also known as gp80), which subsequently associates with a gp130 dimer. The active signaling complex consists of, at minimum, IL-6, IL-6Rα and a dimer of two gp130 proteins that are linked by a disulfide bond. A soluble form of IL-6Rα, namely sIL-6Rα, is generated by proteolytic cleavage of the membrane-bound precursor and can function as an agonistic molecule that can actively participate in cell-to-cell signaling. The second subunit of the IL-6 complex, gp130, also functions as a component of several additional receptor complexes, including leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11. LIF binds to the LIF receptor with low affinity and to a complex of the LIF receptor and gp130 with high affinity, while OSM appears to bind to gp130 with low affinity and to a complex of gp130 and the LIF receptor with high affinity.
Alternative Name:
CD 126, CD126, CD126 antigen, gp80, IL 6R 1, IL 6R alpha, IL 6R, IL-6 receptor alpha chain, IL-6 receptor subunit alpha, IL-6R 1, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL6Q, Il6r, IL6RA, IL6RA_HUMAN, IL6RQ, Interleukin 6 receptor, interleukin 6 receptor, alpha, Interleukin-6 receptor subunit alpha, Membrane glycoprotein 80, MGC30256,
Application Dilution: WB: 1:500~1:2000
Specificity: IL6R polyclonal antibody detects endogenous levels of IL6R protein.
Immunogen:
Recombinant full length Human IL6R.
MW: ~ 52 kDa
Swis Prot.: P08887
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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