Integrin Alpha-V Beta-3 polyclonal, anti-human, mouse, rat, pig, rabbit
€378.00
In stock
SKU
251672
Catalog Nr.: 251672
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, IHC, FC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, IHC, FC
Protein Family: CAM Ligands, Cell Adhesion Molecules, Cellular Antigens, Receptors and Channels
Pathway and Disease: Cancers, Cell Communication, Cell Motility, Immune System, Signaling Molecules and Interaction
Description:
Integrin alpha-V/beta-3, also called vitronectin receptor or CD51/CD61, belongs to the integrin protein family that participates in cell adhesion and cell-surface mediated signalling by forming heterodimers of alpha and beta integrin chains. Integrin alpha-V/beta-3 is a receptor for cytoactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrins recognize the sequence RGD in a wide array of ligands. Defects in CD61 are a cause of Glanzmann thrombasthenia, a blot clot disorder.
Alternate Names: Vitronectin receptor, Integrin alpha-V, Vitronectin receptor subunit alpha, CD51, Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD61, ITGB3, GP3A
Application Notes: E: 1:500-1:1,000; IHC: 1:100-1:500; FC: 1:20-1:100
Accession No.: P06756; P05106
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human integrin alpha-V/beta-3.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Panth KM et al. 2016. Sci Rep. 6: 22198. PMID 26923459.
[2] Crisp J. et al. 2014. Mol Cancer Ther. PMID 24737028.
[3] Du Y. et al. 2012. PLoS ONE. 7(9):e43941. PMID# 23049742.
[4] Gao S. et al. 2013. Nuclear Science and Techniques 24: 040302.
Pathway and Disease: Cancers, Cell Communication, Cell Motility, Immune System, Signaling Molecules and Interaction
Description:
Integrin alpha-V/beta-3, also called vitronectin receptor or CD51/CD61, belongs to the integrin protein family that participates in cell adhesion and cell-surface mediated signalling by forming heterodimers of alpha and beta integrin chains. Integrin alpha-V/beta-3 is a receptor for cytoactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrins recognize the sequence RGD in a wide array of ligands. Defects in CD61 are a cause of Glanzmann thrombasthenia, a blot clot disorder.
Alternate Names: Vitronectin receptor, Integrin alpha-V, Vitronectin receptor subunit alpha, CD51, Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD61, ITGB3, GP3A
Application Notes: E: 1:500-1:1,000; IHC: 1:100-1:500; FC: 1:20-1:100
Accession No.: P06756; P05106
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human integrin alpha-V/beta-3.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Panth KM et al. 2016. Sci Rep. 6: 22198. PMID 26923459.
[2] Crisp J. et al. 2014. Mol Cancer Ther. PMID 24737028.
[3] Du Y. et al. 2012. PLoS ONE. 7(9):e43941. PMID# 23049742.
[4] Gao S. et al. 2013. Nuclear Science and Techniques 24: 040302.
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