CD61 (Integrin β3) (N-terminus) (clone ), anti-human
€388.00
In stock
SKU
MB0145
Background:
Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16α and 8β subunits heterodimerize to produce more than 20 different receptors. Most Integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain Integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster Integrins by binding to adjacent Integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of Integrinmediated responses.
Alternative Name:
Integrin beta-3, Platelet membrane glycoprotein IIIa, Short name=GPIIIa, CD_antigen=CD61, ITGB3, GP3A, CD61, GPIIIa,
Application Dilution: WB: 1:1000
Specificity: This antibody detects endogenous levels of Integrin β3 and does not cross-react with related proteins
Immunogen:
Synthetic peptide, corresponding to the N-terminus of Human Integrin β3.
MW: Predicted band size: 87KDa, Observed band size: 110KDa
Swis Prot.: P05106
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16α and 8β subunits heterodimerize to produce more than 20 different receptors. Most Integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain Integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster Integrins by binding to adjacent Integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of Integrinmediated responses.
Alternative Name:
Integrin beta-3, Platelet membrane glycoprotein IIIa, Short name=GPIIIa, CD_antigen=CD61, ITGB3, GP3A, CD61, GPIIIa,
Application Dilution: WB: 1:1000
Specificity: This antibody detects endogenous levels of Integrin β3 and does not cross-react with related proteins
Immunogen:
Synthetic peptide, corresponding to the N-terminus of Human Integrin β3.
MW: Predicted band size: 87KDa, Observed band size: 110KDa
Swis Prot.: P05106
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
| Is Featured? | No |
|---|
Write Your Own Review