IRAK polyclonal, anti-human, mouse, rat
€396.00
In stock
SKU
253291
Catalog Nr.: 253291
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, ICC, IP
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, ICC, IP
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kappaB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).
Alternate Names: IRAK , IL-1-Receptor Associated Kinase
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IP: 1:100-1:500; ICC: 1:100-1:500
Accession No.: P51617
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human IRAK.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by DEAE chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kappaB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).
Alternate Names: IRAK , IL-1-Receptor Associated Kinase
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IP: 1:100-1:500; ICC: 1:100-1:500
Accession No.: P51617
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human IRAK.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by DEAE chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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