IRS-4 polyclonal, anti-mouse, rat

Protein Family: Receptors and Channels

Pathway and Disease: Endocrine System, Metabolic Disorders, Signaling Molecules and Interaction

Description:
The family of insulin receptor substrates (IRS) has been reported to play an important role for signal transduction of various hormones. Four members of the IRS family have been described. Each IRS is believed to have different functions although the distinct physiological roles of each IRS are unclear. IRS-4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS-4 interacts with cytoplasmic signaling molecules that contain SH2 domains such as IGF1R and FGFR1. IRS-4 is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation. IRS-4 is involved in the proliferation and differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation.

Alternate Names: Insulin receptor substrate 4, IRS-4, 160 kDa phosphotyrosine protein, PY160, IRS4

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: Q9Z0Y7

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of mouse IRS-4.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.