IRS P53 polyclonal, anti-human, mouse, rat

Protein Family: Cytoskeleton Proteins

Pathway and Disease: Cell Motility, Cell Communication

Description:
Insulin receptor substrate P53 (IRS P53) has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of IRS P53, which is involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. IRS P53 has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis.

Alternate Names: IRS P53, Insulin receptor substrate P53, Brain-specific angiogenesis inhibitor 1-associated protein 2, BAI1-associated protein 2, BAI-associated protein 2, BAP2, Insulin receptor substrate protein of 53 kDa, IRSp53, Insulin receptor substrate p53/p58, IRSp53/58, IRS-58, Fas ligand-associated factor 3, FLAF3, BAIAP2

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q9UQB8

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IRS P53.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.