Kappa (clone EBS-huKappa), anti-human

Source:
A BALB/c mouse was immunized with B lymphoma cells.
Fusion partner: SP2/0.

Specifications:
EBS-huKappa reacts with kappa light chain In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of kappa to lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed.

Species reactivity:
Positive: human. Negative: rat.

Applications:
Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
ELISA: +
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Paraffin sections: Citrate

Positive control: 293T, Raji or hPBL cells. Tonsil or Spleen.

References:
- Takahashi, H. et al. Pathol Res Prac189, 300-311 (1993).
- Momose, H., et al. Hum. Pathol23: 1115-1119 (1992)