CD158z (KIR3DL3) polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS70679
Background:
KIR3DL3, the most centromeric gene in the KIR gene cluster, maps to chromosome 19. The 410 amino acid KIR3DL3 (also designated KIRC1, KIR3DL7, KIR44 and CD158Z) protein has three Ig domains, an N-terminal signal sequence, a transmembrane region lacking a positively charged residue, and a long cytoplasmic tail containing an immunoreceptor tyrosine-based inhibitory motif (ITIM), but lacks the stalk region found in other KIRs. KIR3DL3 exhibits low or undetectable levels of expression in peripheral blood NK cells. However, demethylation treatment readily induces KIR3DL3 expression in NK cells, indicating that low KIR3DL3 expression in peripheral blood is due to sustained DNA methylation of a functional promoter.
Alternative Name:
Killer cell immunoglobulin-like receptor 3DL3, CD158 antigen-like family member Z, Killer cell inhibitory receptor, CD_antigen: CD158z, KIR3DL3, CD158Z, KIR3DL7, KIRC1
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: KIR3DL3 polyclonal antibody detects endogenous levels of KIR3DL3 protein.
Immunogen:
Recombinant protein of human KIR3DL3.
MW: ~ 45 kDa
Swis Prot.: Q8N743
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
KIR3DL3, the most centromeric gene in the KIR gene cluster, maps to chromosome 19. The 410 amino acid KIR3DL3 (also designated KIRC1, KIR3DL7, KIR44 and CD158Z) protein has three Ig domains, an N-terminal signal sequence, a transmembrane region lacking a positively charged residue, and a long cytoplasmic tail containing an immunoreceptor tyrosine-based inhibitory motif (ITIM), but lacks the stalk region found in other KIRs. KIR3DL3 exhibits low or undetectable levels of expression in peripheral blood NK cells. However, demethylation treatment readily induces KIR3DL3 expression in NK cells, indicating that low KIR3DL3 expression in peripheral blood is due to sustained DNA methylation of a functional promoter.
Alternative Name:
Killer cell immunoglobulin-like receptor 3DL3, CD158 antigen-like family member Z, Killer cell inhibitory receptor, CD_antigen: CD158z, KIR3DL3, CD158Z, KIR3DL7, KIRC1
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: KIR3DL3 polyclonal antibody detects endogenous levels of KIR3DL3 protein.
Immunogen:
Recombinant protein of human KIR3DL3.
MW: ~ 45 kDa
Swis Prot.: Q8N743
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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