KISS1 polyclonal, anti-human, mouse, rat
€378.00
In stock
SKU
251265
Catalog Nr.: 251265
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction, Cancers, Cell Growth and Death
Description:
KISS1 (Metastasis-suppressor KiSS-1) is a metastasis suppressor protein found in malignant melanomas and in some breast cancers. KISS1 regulates events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. KISS1 generates a C-terminally amidated peptide, metastin, which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of this receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca2+ levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty.
Alternate Names: Metastasis-suppressor KiSS-1, Kisspeptin-1, KiSS-1, Metastin, Kisspeptin-14, Kisspeptin-13, Kisspeptin-10, KISS1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: Q15726
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human KISS1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Luo QQ et al. 2016. J Chin Med Assoc. 79(10): 546-53. PMID 27373140.
[2] Luo Q et al. 2016. Life Sci. 153: 207-12. PMID 27212704.
[3] Zhou Q et al. 2014. Reprod Biol Endocrinol. 12: 127. PMID 25542298.
Pathway and Disease: Signaling Molecules and Interaction, Cancers, Cell Growth and Death
Description:
KISS1 (Metastasis-suppressor KiSS-1) is a metastasis suppressor protein found in malignant melanomas and in some breast cancers. KISS1 regulates events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. KISS1 generates a C-terminally amidated peptide, metastin, which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of this receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca2+ levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty.
Alternate Names: Metastasis-suppressor KiSS-1, Kisspeptin-1, KiSS-1, Metastin, Kisspeptin-14, Kisspeptin-13, Kisspeptin-10, KISS1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: Q15726
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human KISS1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Luo QQ et al. 2016. J Chin Med Assoc. 79(10): 546-53. PMID 27373140.
[2] Luo Q et al. 2016. Life Sci. 153: 207-12. PMID 27212704.
[3] Zhou Q et al. 2014. Reprod Biol Endocrinol. 12: 127. PMID 25542298.
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