KLF4 (clone 1E6), anti-human
€394.00
In stock
SKU
253064
Catalog Nr.: 253064
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB, IHC, IF
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB, IHC, IF
Protein Family: Transcription Factors
Pathway and Disease: Signaling Molecules and Interaction, Transcription
Description:
KLF4 (Krueppel-like factor 4) is a transcription factor, can act both as activator and as repressor. KLF4 binds the 5'-CACCC-3' core sequence of promoters, and also binds to its own promoter region of its own gene and can activate its own transcription. KLF4 regulates the expression of key transcription factors during embryonic development. KLF4 plays an important role in maintaining embryonic stem cells, in preventing their differentiation. POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differenciated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
Alternate Names: Krueppel-like factor 4, Epithelial zinc finger protein EZF, Gut-enriched krueppel-like factor, KLF4, EZF, GKLF
Application Notes: WB: 1:200-1:1000; IHC: 1:200-1:1000; IF: 1:200-1:1000
Accession No.: O43474
Antigen: Purified recombinant fragment of human KLF4 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction, Transcription
Description:
KLF4 (Krueppel-like factor 4) is a transcription factor, can act both as activator and as repressor. KLF4 binds the 5'-CACCC-3' core sequence of promoters, and also binds to its own promoter region of its own gene and can activate its own transcription. KLF4 regulates the expression of key transcription factors during embryonic development. KLF4 plays an important role in maintaining embryonic stem cells, in preventing their differentiation. POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differenciated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
Alternate Names: Krueppel-like factor 4, Epithelial zinc finger protein EZF, Gut-enriched krueppel-like factor, KLF4, EZF, GKLF
Application Notes: WB: 1:200-1:1000; IHC: 1:200-1:1000; IF: 1:200-1:1000
Accession No.: O43474
Antigen: Purified recombinant fragment of human KLF4 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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