KLHL13 (clone 8D1), anti-human
€363.00
In stock
SKU
253027
Catalog Nr.: 253027
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: E, WB, IHC, IF, FC
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: E, WB, IHC, IF, FC
Protein Family: Cellular Antigens
Pathway and Disease: Cell Growth and Death
Description:
KLHL13 (Kelch-like protein 13) is a 604 amino acid long protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Via its BTB and C-terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL-3 ligase.
Alternate Names: Kelch-like protein 13, BTB and kelch domain-containing protein 2, BKLHD2, KIAA1309, KLHL13
Application Notes: E: 1:10000; WB: 1:500-1:2000; IF: 1:200-1:1000; IHC: 1:200-1:1000; FC: 1:200-1:400
Accession No.: Q9P2N7
Antigen: Purified recombinant fragment of human KLHL13 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cell Growth and Death
Description:
KLHL13 (Kelch-like protein 13) is a 604 amino acid long protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Via its BTB and C-terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL-3 ligase.
Alternate Names: Kelch-like protein 13, BTB and kelch domain-containing protein 2, BKLHD2, KIAA1309, KLHL13
Application Notes: E: 1:10000; WB: 1:500-1:2000; IF: 1:200-1:1000; IHC: 1:200-1:1000; FC: 1:200-1:400
Accession No.: Q9P2N7
Antigen: Purified recombinant fragment of human KLHL13 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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