KLHL21 (clone 2H4), anti-human
€394.00
In stock
SKU
253023
Catalog Nr.: 253023
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB, IHC
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB, IHC
Protein Family: Cellular Antigens
Pathway and Disease: Cell Growth and Death
Description:
KLHL21 (Kelch-like protein 21) protein is part of the ubiquitin-proteasome pathway. It is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR (KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
Alternate Names: KIAA0469, MGC99635, KLHL21, Kelch-like protein 21
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: Q9UJP4
Antigen: Purified recombinant fragment of human KLHL21 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cell Growth and Death
Description:
KLHL21 (Kelch-like protein 21) protein is part of the ubiquitin-proteasome pathway. It is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR (KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
Alternate Names: KIAA0469, MGC99635, KLHL21, Kelch-like protein 21
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: Q9UJP4
Antigen: Purified recombinant fragment of human KLHL21 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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