KLHL22 (clone 7B10), anti-human
€394.00
In stock
SKU
253068
Catalog Nr.: 253068
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB, IF
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: WB, IF
Protein Family: Cellular Antigens
Pathway and Disease: Cell Growth and Death
Description:
KLHL22 (Kelch-like protein 22) is a 634 amino acid protein that is related to the Drosophila kelch protein, which is required to maintain Actin organization in ovarian ring canals. Mutations affecting Kelch function result in the failure of Kelch to associate with the ring canals and subsequent female sterility. Human KLHL22 protein contains six kelch repeats and one BTB (POZ) domain. The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. There are two isoforms of KLHL22 that are produced as a result of alternative splicing events.
Alternate Names: KELCHL, KLHL22, Kelch-like protein 22
Application Notes: WB: 1:200-1:1000; IF: 1:200-1:1000;
Accession No.: Q53GT1
Antigen: Purified recombinant fragment of human KLHL22 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cell Growth and Death
Description:
KLHL22 (Kelch-like protein 22) is a 634 amino acid protein that is related to the Drosophila kelch protein, which is required to maintain Actin organization in ovarian ring canals. Mutations affecting Kelch function result in the failure of Kelch to associate with the ring canals and subsequent female sterility. Human KLHL22 protein contains six kelch repeats and one BTB (POZ) domain. The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. There are two isoforms of KLHL22 that are produced as a result of alternative splicing events.
Alternate Names: KELCHL, KLHL22, Kelch-like protein 22
Application Notes: WB: 1:200-1:1000; IF: 1:200-1:1000;
Accession No.: Q53GT1
Antigen: Purified recombinant fragment of human KLHL22 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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